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These enzymes are responsible for creating prostaglandins, which are chemicals that signal pain and cause inflammation

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Matsushita M., Fujita K., Nonomura N

It is important to note that higher doses may lead to more pronounced side effects

and international prices and warned that broad Medicare coverage of obesity drugs could add tens of billions of dollars in federal spending annually

Concomitantly administered means that the two drugs are taken at, or nearly at, the same time
