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found that semaglutide significantly reduced DPN-associated pain behaviors and neuroinflammation in STZ-induced diabetic rats [86]
Ex-4 is high in lipophilicity but is needed in high doses for penetration into the BBB [65]
doi: 10.1001/jama.2024.2252 21 ZakariaHAlshehhiSCaccelliMOzkanCKattanJJafaarZet al
Diabetes 51 , S434442 (2002)

OR: odds ratio

control, despite matching for baseline BMI/age [27]