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When to contact your provider: Persistent vomiting (more than 12 hours) Severe abdominal pain Signs of pancreatitis (pain radiating to the back, fever, rapid pulse) No weight loss after 8 weeks at the same dose Hypoglycemic symptoms (shakiness, confusion, sweating) if you're on other diabetes medications The 16-week decision point: At 16 weeks (four months), you and your provider should evaluate total weight loss

This can happen when medication is exposed to excessive heat , left in direct sunlight, or stored beyond its expiration date

The STEP trial program, which included over 15,000 participants, demonstrated that semaglutide produces average weight loss of 15-17% of body weight when combined with lifestyle modifications

However, we do know a few things based on emerging studies and general knowledge about weight loss and low-fat dieting (which is generally recommended while taking GLP-1s)

Surampudi, V

Optimizing GLP-1 and Intermittent Fasting for Maximum Results Success with combined therapy depends on matching medication dosage to fasting intensity