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The metabolic adaptations that defend higher body weight do not disappear just because weight has been lost

Factors like stress, illness, weight changes, travel, or hormonal fluctuations can sometimes cause a delay

N Engl J Med 2017;377:723e32

[DOI] [PMC free article] [PubMed] [Google Scholar] 115.9

2 Study Flow Diagram for Selecting Patients Initiating Glucagon-Like Peptide-1 Receptor Agonist (GLP-1RA) or Sodium-Glucose Cotransporter-2 Inhibitor (SGLT-2i)

Excess weight is known to reduce fertility
