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Contact your provider promptly if you experience severe or persistent gastrointestinal symptoms while using both medications, including: severe diarrhea lasting more than 24 hours, signs of dehydration (decreased urination, dizziness, extreme thirst, dry mouth), persistent vomiting preventing adequate fluid intake, severe abdominal pain or cramping, or blood in stool

[7] Specifically, for every 1 g increase in 24-h urinary sodium excretion, systolic blood pressure increases by 2.11 mmHg, and diastolic blood pressure by 0.78 mmHg

Again, the significance of this is unclear but would warrant prolonged observation of diabetic patients on GLP-1 receptor agonists

Mechanisms and Benefits Direct Delivery : Bypassing the BBB through CSF administration ensures that stem cells reach the target areas in the CNS without being filtered out by the barrier

So, I decided to try both

It slows gastric emptying, which means food stays in the stomach longer and you feel full sooner