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When to seek urgent medical advice : Sudden worsening of joint pain, swelling, or stiffness Signs of infection (fever, malaise, localised warmth) Severe abdominal pain (potential pancreatitis if on GLP-1 therapy) Unexplained persistent nausea or vomiting Any concerning new symptoms after starting any new medication According to NICE Quality Standard 33, if you have suspected persistent synovitis, you should be referred to rheumatology within 3 working days and assessed within 3 weeks