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Patients with proliferative retinopathy or maculopathy resulting in active treatment were excluded from the PIONEER 6 CVOT, in which no apparent imbalance was observed between oral semaglutide and placebo in the AE reporting of diabetic retinopathy over 16 months (66)

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Moreover, several second-generation medicines shown substantial cardiovascular advantages in extensive outcome studies, therefore enhancing their therapeutic efficacy beyond basic glucose regulation (Nauck and Meier 2019)

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