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The dual GLP-1/GIP receptor agonist DA4-JC shows superior protective properties compared to the GLP-1 analogue liraglutide in the APP/PS1 mouse model of alzheimers disease

Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats

4) Long-Lasting Action Unlike natural GLP-1, which is degraded within minutes by the enzyme DPP-4, semaglutide is structurally modified to resist enzymatic breakdown

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doi:10.1016/j.regpep.2012.12.012 45

52,57,58 Moreover, the effect was consistent across all HRQoL domains (e.g