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Ex4 increased GCaMP6s signals in VTA-projecting NTS GABA neurons during cocaine-paired cue presentation, while chemogenetic silencing of this circuit abrogated the Ex4-induced reduction in cocaine seeking

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For a broader understanding of how these systems connect, see our Human Microbiome Hub

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That is, investigations are warranted to better understand the potential benefit of combined use of GLP-1 RAs and SGLT2 inhibitors in HF with specific focus on the sequence of treatment initiation and the suitable population, including by HF phenotype and presence of diabetes

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