glp 1 agonist and depression Psychotropic effects of GLP-1R agonists Insights into a possible role

A meta-analysis including four RCTs (published 20212023) evidenced that danuglipron is reliable for glycemic control and weight reduction in T2D patients

1 GLP-1 RAs should be titrated until A1C goal, maximum dose, or patient tolerability has been met

Therefore, almost all scientific guidelines now recommend specific treatments for patients with type 2 diabetes based on CVOTs data, namely adding to metformin a SGLT-2 inhibitor or a GLP-1RA with proven CV disease benefit in patients with type 2 diabetes and CV disease, established kidney disease, or HF [7,8,9,10]

they may positively influence survival when assessing incretin mimetics in a post-diagnosis setting

conventional hypoglycemic drugs: arrhythmic burden, hospitalizations for heart failure, and CRTd responders rate

Continued tirzepatide therapy sustained and even augmented initial weight loss, whereas discontinuation resulted in marked weight regain, confirming its durable effectiveness and good tolerability for long-term weight management (31)