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The comparison between the group with normal renal function and the group with severe RI did not demonstrate equivalence (the 95% CI exceeded the no effect limits), and the mean semaglutide exposure was 22% higher in the severe RI group

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Until that data exists, Metformin remains the evidence-based choice for cardiovascular protection

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Physical Activity Level The STEP trials included modest exercise recommendations (150 minutes weekly of moderate activity)

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