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GLP1RAs are increasingly recognised for their potential neuropsychiatric effects beyond glycaemic control and weight loss

Summary Preclinical rodent model studies indicate that ghrelin signaling promotes conditioned appetitive behaviors and eating in response to food-associated cues, possibly by contributing to an interoceptive state analogous to fasting, by signaling meal anticipation, and/or by increasing the palatability of food

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But even the anti-inflammatory narrative of how GLP-1 drugs work is complicated, depending on the type and location of inflammation involved

Monitoring your health while using a GLP-1 receptor agonist is important, and certain symptoms or situations, such as the ones below, should prompt a consultation with a doctor: New or worsening gastrointestinal symptoms, such as persistent nausea, vomiting, diarrhoea, or signs of dehydration 7 , 27

Solini A, Giannini L, Seghieri M, et al