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In terms of efficacy, the treatment group receiving oral semaglutide achieved statistically significant reductions from baseline in A1C and body weight when compared with placebo

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Common side effects include: Nausea and vomiting Diarrhoea or constipation Reduced appetite Abdominal discomfort or bloating Injection site reactions (redness, itching, or mild swelling) These effects can often be managed by eating smaller, lower-fat meals, avoiding lying down immediately after eating, staying well hydrated, and adhering to the gradual dose-escalation schedule

Biochem J 466: 203218

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But here's what your doctor might not have emphasised: research shows that up to 40% of the weight lost on these medications can come from lean muscle mass, not just fat