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Recent years have also seen a surge in demand for combination therapies and next-generation multi-agonists, reflecting evolving treatment paradigms and patient preferences

Rebound or retention: a meta-analysis of weight regain after the discontinuation of glucagon-like peptide-1 (GLP-1) receptor agonists and other anti-obesity drugs

Heres where the evidence stands today, and what experts say you should think about before taking these types of medications

If it looks cloudy, milky, or has changed color (such as turning slightly yellow or brown), do not use it

Safety and effectiveness of longer-term phentermine use: Clinical outcomes from an electronic health record cohort, Obesity (2019) Qsymia, DailyMed (2024) Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial, The Lancet (2011) Long-term drug treatment for obesity: A systematic and clinical review, JAMA (2014) Lillys Zepbound (tirzepatide) superior to Wegovy (semaglutide) in head-to-head trial showing an average weight loss of 20.2% vs

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