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Background Renin-angiotensin system inhibitors (RASi) and sodium glucose cotransporter inhibitors (SGLT2i) are known for their kidney protective properties, but both show significant residual risk in large outcome trials

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Osteoporosis was induced in female rats by ovariectomy, and the ovariectomized rats were treated with alendronate as standard treatment with a dose of 3 mg/kg orally and semaglutide with two doses (150 mcg/kg and 300 mcg/kg) S.C

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Methods This systematic review was conducted across PubMed/MEDLINE and Web of Science

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist with 94% structural homology to native GLP-1. It has demonstrated significant efficacy in glycemic control and weight management research applications