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Hydration optimization is paramount

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Systemic inflammation driven by steatosis and necro-inflammatory changes in MASLD activates pathways such as toll-like receptors (TLR) and Nuclear Factor-kappa B (NF-B), causing cardiac and vascular tissue damage

Ozempic still slows gastric emptying, reduces appetite, and improves insulin sensitivity through the same GLP-1 pathway that Mounjaro also uses

N Engl J Med 358:25602572 The Action to Control Cardiovascular Risk in Diabetes Study Group (2008) Effects of intensive glucose lowering in type 2 diabetes

These approaches should be viewed as complementary to, not replacements for, medical treatment when indicated, and may not produce significant GLP-1-mediated clinical effects on their own