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GLP-1 is a hormone that the gut produces after eating to regulate blood sugar, slow digestion and manage hunger

Purpose of Review: This article summarizes the medical management of obesity with an emphasis on incretin-based therapeutics that target the neuro-hormonal basis of obesity.Recent Findings: Medications that mimic the effect of incretins, a group of peptide hormones released in response to nutrient intake that regulate appetite, result in potent and durable weight loss

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Glucagon-like peptide-1 receptor (GLP-1R) is a versatile therapeutic target that regulates glucose homeostasis, cardiovascular function, neuroprotection, and immune responses

Learn what happens when Ozempic is discontinued, including weight regain, blood sugar changes, and strategies for safe transition off treatment.

Lack of self-inhibition by excess doses of the unlabeled [Ser8]GLP-1 either iv or by in situ brain perfusion, indicating the absence of a saturable transport system at the BBB