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A funnel plot is suggestive of the presence of most of the studies outside the plot, hence it is likely that significant publication bias is present DISCUSSION Obesity has severe health consequences, with each 5 kg/m 2 increase in BMI beyond the normal range linked to a 30% increase in mortality and a potential reduction in life expectancy by up to 10 years.[16] Conversely, significant weight loss is associated with metabolic and non-metabolic benefits

31 Lifestyle factorsparticularly nutrition and exerciseare crucial for maximizing the benefits of the medication, achieving sustainable weight loss, and promoting long-term well-being

By focusing on adequate protein intake, staying well-hydrated, moving your body, and dressing warmly, you can comfortably support your system through this transition

[DOI] [PMC free article] [PubMed] [Google Scholar] [82].Rinaman L

The relationship between weight loss medications and cortisol levels remains an area of active investigation, with limited direct evidence specifically examining tirzepatide's effects on cortisol