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Online Journal | Justin Plank | January 2025 Background Every year, the United States spends an estimated $173 billion treating obesity-related diseases like diabetes and heart disease, more than the annual budgets of 42 U.S

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A phase 3 trial found the once-daily pill orforglipron lowered blood sugar and body weight more than oral semaglutide in adults with type 2 diabetes.

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Conclusions This open-label, single-center pilot study suggests that GLP-1-RAs are an effective and safe treatment option for achieving significant weight loss with a favorable effect on headache, leading to reduced acetazolamide dosage in pwIIH