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Gastrointestinal disorders were reported by a greater proportion of participants on all doses of oral semaglutide than participants on sitagliptin 100 mg, and increased in frequency as the oral semaglutide dose increased

The development of tesofensine represents a significant step forward in obesity treatment

Most people taking semaglutide notice appetite suppression within 3-5 days of their first dose, though significant weight loss generally takes 4-8 weeks to become measurable

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In animal studies, GLP-1 agonists triggered anxiety early in treatment which then subsided and shifted toward reduced depression-like behaviour with continued use