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Relative to placebo, tirzepatide was also associated with significant improvements in BMI, HbA1c, fasting glucose, fasting insulin, lipid levels, and systolic and diastolic pressure, which emphasizes the need to continue pharmacotherapy to prevent weight regain and ensure the maintenance of cardiometabolic benefits (Aronne et al

Cumulatively, the data from this trial indicate that once-weekly exenatide is superior for achieving target HbA1c level and blood glucose level without increasing the rate of hypoglycemia5)

For more than 20 years, that promise held

Proper counseling, labeling, and dispensing protocols are essential to reduce the risk of overdoses and associated hospitalizations

and Van Raalte D

and H.G., the Medical Research Council UK (MR/N02589X/1 to S.T.), a British Heart Foundation Postdoctoral Fellowship (FS/IPBSRF/20/27001 to M.K.H.), a Wellcome Trust Sir Henry Dale Fellowship (223279/Z/21/Z to D.B.), and a grant from the European Foundation for the Study of Diabetes Germany (Merck Sharpe Dohme grant to S.T