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[DOI] [PubMed] [Google Scholar] 78.Seko Y., Sumida Y., Tanaka S., Mori K., Taketani H., Ishiba H., Hara T., Okajima A., Umemura A., Nishikawa T., et al

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With Eli Lilys Mounjaro (tirzepatide) also on the horizon (NICEs recent rejection notwithstanding), the treatment paradigm and market opportunity for obesity investors appears to be firmly at an inflection point

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These agents work by stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

Our results suggest that GABA and glycine stimulate electrical activity and GLP-1 release from GLUTag cells by ligand-gated ion channel activation, a mechanism that might be important in responses to endogenous ligands from the enteric nervous system or dietary sources