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Youve likely heard about glucagon-like peptide-1 agonists commonly referred to as GLP-1 medications, and more widely recognized through pharmaceutical brand names like Ozempic and Mounjaro.

This triple pathway interest makes Retatrutide relevant to laboratory studies involving receptor pathway comparison, metabolic signalling, glucose response models, appetite-related pathway modelling, energy balance research and cardiometabolic research frameworks

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In this review, we summarize the state-of-the-art evidence regarding the epidemiology and pathophysiology of diabetic HFpEF, and the landscape of the novel antidiabetic drugs in the treatment of diabetic HFpEF, as well as discuss the relevant mechanisms, aiming to broaden the understanding of diabetic HFpEF and gain new insight into the treatment of this disease