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The proglucagon gene encodes a 180-amino acid precursor that, depending on the tissue-specific expression of processing enzymes, yields different active peptides: in the pancreatic alpha cells, PCSK2 processing produces glucagon

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40 During dose escalation in the clinical trials, subjects were allowed to remain at a GLP-1 dose for up to 8 weeks, as needed, to allow GI side effects to dissipate

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