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Glucagon-like peptide-1 (GLP-1) reduces mortality and improves lung function in a model of experimental obstructive lung disease in female mice

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The compound is contraindicated in individuals with a personal history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, a precaution based on animal model findings rather than human clinical evidence

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The search strategy combined Medical Subject Headings (MeSH) and free-text terms, including testosterone replacement therapy, TRT, low testosterone, hypogonadism, GLP-1 receptor agonist, semaglutide, tirzepatide, lean mass, fat-free mass, skeletal muscle, body composition, weight loss, and sarcopenia. Boolean operators (AND/OR) were applied as appropriate

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