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Baseline evaluation with dilated fundus examination prior to or shortly after GLP-1 RA initiation is recommended, particularly in patients with more advanced diabetic retinopathy

Astrocytes activation may be either beneficial, promoting tissue repair and homeostasis, or detrimental, exacerbating inflammatory reactions and tissue damage, depending on the stimuli nature [15]

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Dramatically increased efficacy, uptake, and adherence could lead to positive upside impacts relative to our central scenario best-estimate assumptions