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The mechanism of action involves several physiological effects: GLP-1 receptor agonists stimulate insulin secretion in a glucose-dependent manner, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways

doi: 10.1016/j.neulet.2015.12.007 196 SharmaMKJalewaJHolscherC

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5 Future directions The potential of GLP-1RAs as dual-action therapies, targeting both metabolic dysfunction and immune dysregulation, makes them particularly compelling candidates for early PsA, where intervention may alter disease trajectory

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Clinical investigations have demonstrated that AMPK signaling improves diabetes consequences such brain problems
