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[13] [16] For patients taking GLP-1/GIP medicinesparticularly those on concurrent metformin, following restricted diets, or with pre-existing malabsorption conditions proactive monitoring and management of B12 status should be considered an integral component of comprehensive care

The development of reliable biomarkers is also critical for monitoring therapeutic response and advancing clinical translation

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Supplement-Based Approaches Selecting between berberine supplementation and GLP-1 therapy depends on your weight loss goals, timeline, and underlying metabolic profile