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Sitagliptin, anagliptin, gemigliptin, and teneligliptin form class 3 of the DPP-4 inhibitors (see Figure 2) ( Figure 2 The clinically most relevant and important action of DPP-4 inhibitors is the endogenous elevation of the incretin hormone concentration of GLP-1 that consecutively leads to a glucose-dependent stimulation of insulin secretion and an inhibition of glucagon secretion ( This article gives an overview on the characteristics of the various DPP-4 inhibitors in clinical use and highlights the positioning of the drug class in the guidelines for the treatment of type 2 diabetes

The GLP-1 class of medicines is almost 20 years old

Heart disease

GLP-1 medications are not appropriate for all patients

doi: 10.1007/s00125-017-4303-6 [DOI] [PMC free article] [PubMed] [Google Scholar] 36

Ozempic, a brand of semaglutide, reports diarrhea in roughly 8 to 20% of users, usually mild and early