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40 Nevertheless, accumulating evidence indicates that CR is detrimental to skeletal metabolism, as evidenced by reductions in BMD and bone mineral content (BMC), diminished bone formation indices (e.g., bone formation rate, osteoblast number), and a concomitant increase in bone resorption

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Randomized clinical trials are more important than online extrapolation

Because phentermine does not produce the metabolic or hormonal changes that GLP-1 medications do, weight regain after stopping is common if lifestyle changes have not been embedded

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