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However, the replacement might be performed only under strict medical supervision
When patients stop taking tirzepatide, weight tends to return within months
doi: 10.1016/j.jacl.2012.03.003
, Donath, M
Polyethylene glycol Loxenatide (PEX-168) The early GLP-1RA takes repeated injections and has a high rate of digestive system side effects, limiting its use
In a pharmacological context, food intake is minimally impacted by interference with endogenous GLP1/GLP1 receptor, while eating is decreased by activation of GLP1 neurons within the nucleus tractus solitarius (Cheng et al., 2020
