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Incretin-based drugs and the kidney in type 2 diabetes: choosing between DPP-4 inhibitors and GLP-1 receptor agonists

Beta blockers can be taken concurrently with retatrutide, but they may not fully control the heart rate increase because retatrutide works through the glucagon receptor cAMP-PKA pathway rather than the sympathetic nervous system that beta blockers target

doi: 10.1038/nm919 118 AbbasTFaivreEHolscherC

Similar to Semaglutide, the GLP-1R agonist Dulaglutide is fused to a modified immunoglobulin Fc fragment to extend the peptides half-life

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