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Discontinuation due to adverse events was 11.3% at the highest dose versus 4.9% on placebo

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However, the absence of prospective short- and long-term outcome data underscores the need for systematic investigation to define optimal timing, safety parameters, and oncologic efficacy of weight-loss interventions in this high-risk population.

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Furthermore, our obesogenic environment poses an insurmountable obstacle to weight loss without professional support for most PwO

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