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The umbrella review included thirty-one RCTs involving 165,858 participants with either T2DM, prediabetes, or at high risk of diabetes (Zhu et al., 2020)
Lilly is studying retatrutide in several Phase 3 clinical trials to evaluate its potential efficacy and safety in obesity and type-2 diabetes, along with other adjacent comorbidities including knee osteoarthritis pain, moderate-to-severe OSA, chronic low back pain, metabolic dysfunction-associated steatotic liver disease and several others
As with any medication, both Mounjaro and Ozempic may have potential side effects
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Administration in Special Populations Administration to Elderly Patients Older adults generally tolerate semaglutide well, though careful monitoring is advised
