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In this case, the affinity would weaken if Glu was replaced with a lactam bridge because the charge would be dispersed

The mechanism involves several pathways: slowing gastric emptying (which helps people feel full longer), reducing appetite signals in the brain, and improving how the body processes glucose

This is like patients who tend to lose significant weight early on during a diet or vigorous exercise program

First, the pharmaceutical pathway through Health Canada, which requires FDA approval followed by a separate Canadian submission and review process

As such, there is growing interest in repurposing medications with novel mechanisms of action

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