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The data from only the mice completing the protocol were analyzed since the most of the Pdx1-Cre;Trp53 R172H ;Rb f/f mice developing insulinoma die within 2 weeks after presenting with hypoglycemia as previously reported 22

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DOI: 10.1001/jamanetworkopen.2022.31982

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First, we considered the possibility that responses mediated by GLP-1R might be modulated by the state of the Y1-R