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Hormonal and metabolic adaptation: The body has complex counter-regulatory mechanisms

(B) Exogenously administered GLP-1, as the one contained in NAOMs, is readily available in systemic circulation, bypassing portal circulation and the deleterious effects of DPP-4

Davis TME, Coleman RL, Holman RR, UKPDS Group

Comparing mazdutide to well-known therapies such as semaglutide (GLP-1 receptor agonist) and tirzepatide (GLP-1/GIP dual agonist) highlights its potential advantages and limitations

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