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150,152,153 Activation of the GLP-1R can enhance insulin secretion, reduce glucagon secretion, delay gastric emptying, 154 and suppress appetite

alternative contraception is recommended for 4 weeks after starting or increasing doses

That increased volume stretches the intestinal wall, which triggers peristaltic contractions

Both in vivo and in vitro studies demonstrated that liraglutide treatment inhibited the activation of NLRP3 inflammasome in the lungs of pulmonary fibrosis model mice and in profibrotic cytokine-challenged fibroblasts

Equally, policy-driven studies are needed to evaluate cost-containment models, equitable access strategies, and the public health implications of widespread GLP-1RA adoption

Addressing equity issues is critical to ensure that all individuals, regardless of socioeconomic status, can benefit from these advancements in obesity treatment