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Body-image distress is increased in women with polycystic ovary syndrome and mediates depression and anxiety

Wharton S, Davies M, Dicker D, Lingvay I, Mosenzon O, Rubino DM, et al

This effect seems to be mediated by activation of the AMPK/PGC-1a (peroxisome proliferation-activated receptor --coactivator 1a) pathway since lentivirus-induced downregulation of PGC-1 reversed the neuroprotective effect [46, 47]

This information supports the hypothesis that dysfunction in obese individuals may originate from changes in taste bud morphology, which result from a reduction in taste bud abundance and altered signaling (104)

Weight loss is broadly viewed as positive, with leaner and smaller body sizes generally being more aligned with westernized body norms

The Food and Drug Administration approved Eli Lilly's blockbuster weight loss drug Zepbound for treating patients with the most common sleep-related breathing disorder