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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily used to manage type 2 diabetes and, more recently, for weight management in certain patient groups

3).These data suggest that P5 has superior antihyperglycaemic efficacy in diabetic ob/ob mice

Liraglutide and semaglutide were predominantly studied in the context of opioid and alcohol use disorders

These expirations threaten Pfizers revenue, although the company has moved to counter the trend through a series of aggressive M&A deals including Seagen (ADC specialist), Trillium Therapeutics (oncology), Biohaven (neurology), Global Blood Therapeutics (rare diseases), and Arena Pharmaceuticals (immunology and inflammation)

Asmar, C.M

Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases