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Our study quantified the running costs in the first 2 years after the initial treatment for both GLP-1 RAs and MBS and found that the mean ongoing costs for GLP-1 RAs over 2 years were $11 689 (nearly 23%) higher than those for MBS

These findings are encouraging as they indicate that GLP-1 RAs can intervene in one of the root causes of PD neurodegeneration

Manufacturers generally warn against using these drugs if a person has a personal or family history of medullary thyroid carcinoma, a type of thyroid cancer, or multiple endocrine neoplasia syndrome type 2 (MEN 2), an endocrine system condition

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Collectively, these factors contribute to the currently higher costs of goods compared to injectable GLP-1s, reflecting additional material, process and quality complexity along the upstream value chain
Additionally, the study reported lower all-cause mortality among GLP-1 users, which, while encouraging, complicates interpretation of the dementia findings patients who live longer may simply have more time to develop cognitive symptoms
