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This became known as the "incretin effect," which led researchers to hypothesize that some hormones released from the gut were enhancing insulin secretion

The average duration of diabetes was 6.2 years, and patients were on at least 1,500 mg of metformin with a mean HbA1c of 8%

Effect of GIP and GLP-1 antagonists on insulin release in the rat

For persistent GERD symptoms, physicians typically recommend an 8-week PPI trial, followed by step-down to the lowest effective dose

For GLP-1 drugs, the risks include: Increased anxiety or panic from unstable blood sugar Triggering or worsening depression Heightened risk of obsessive eating behaviors Potential for self-esteem issues or body image dysmorphia For someone already struggling with mental health, these risks are compounded making proper medical oversight essential

For some older adults, experts said, losing muscle might make it harder to use stairs or to sit or get up from a chair without assistance