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Description
in the early 2020s
WCDD301 does not affect the secretory function of cells over a range of concentrations (Figure 2, DF), and WCDD301 administration achieves euglycemia without clinical signs of illness, hepatotoxicity, or nephrotoxicity (Supplemental Table 2)
Yet, the actual risk of metformin-associated lactic acidosis (MALA) appears to be extremely rare (approximately 3 cases per 100,000 patient-years)
Subsequently, randomized trials in obese HFpEF population will be essential to establish the efficacy and safety of BSx, thereby providing an evidence-based foundation for BSx in HFpEF management
METHODS Ethical compliance The SRM was registered with PROSPERO (CRD42024574086), and the protocol summary can be accessed online
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