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These findings highlight the importance of targeted therapeutic strategies based on HF phenotypes

The regulation of energy homeostasis by centrally-produced GLP-1 is not yet fully understood

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Recent studies indicate that glucagon-like peptide 1 (GLP-1) receptor agonists, currently used in the management of type 2 diabetes, exhibit neurotrophic and neuroprotective effects in amyloid- (A) toxicity models of Alzheimers disease (AD)

We review recommendations that have been published to date, and consider the best availablebut currently limitedevidence from large observational studies and the DARE-19 randomized control trial

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