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However, when combined with insulin or sulfonylureas, GLP-1-RAs are associated with increased vulnerability to hypoglycemia [36,77]
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It has been shown that obese women have a lower LH amplitude and mean serum level of LH, which might result in abnormal ovarian follicular recruitment and development, which causes longer follicular phases indicating ovulatory problems [86,111]
95% CI, 0.380.95

Conclusions and future directions This study provides a comprehensive evaluation of gastrointestinal adverse events associated with GLP-1 RAs in non-diabetic individuals with overweight or obesity