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HR, 1.12
Other obesity management approaches While GLP-1 RAs have demonstrated substantial efficacy in promoting weight loss, it is useful to first examine other treatment modalities in obesity management
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doi: 10.1038/s41586-024-07419-8
Its a small trial with only 1-year follow up and lacking hard endpoints such as hospitalization or cardiovascular deaths, but the results for symptomatic relief and gain in physical activity are certainly very encouraging
No clinical trial has answered this question definitively yet, but the mechanistic rationale is compelling
