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Ratio (535/460 nm) BRET readings were normalised to baseline and to average vehicle readings for agonist-specific responses

STEP clinical trials showed average weight loss of 1022% of body weight over 68 weeks, depending on maintenance dose

doi: 10.1155/2011/806896

This includes considerations around insulin dosing and continuous glucose monitor (CGM) adjustments, ketone management, monitoring and mitigating side effects (especially gastrointestinal) and complications like eye disease, and more

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Insulin-receptor substrate-2 (Irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liver