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Enteroendocrine L-cell derived peptide hormones, notably glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2), have become important targets in the treatment of type 2 diabetes, obesity and intestinal diseases

This means: * It can be taken at any time of day

However, more studies are needed.

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Research published in the Journal of Clinical Endocrinology and Metabolism demonstrated that drinking 500ml of water increases metabolic rate by approximately 30% for about an hour