glp-1 agonists and sglt2 inhibitors Receptor in Kidney Transplantation: A Systematic Review and Meta-Analysis Common systemic effects of either

26 For example, in rheumatoid arthritis-induced mouse, liraglutide administration lessened synovial inflammation and decreased pro-inflammatory cytokine production, resulting in better outcomes of joint damage

They also reduce visceral and ectopic fat that accumulates around the abdomen and organs, which may help curb the inflammatory and metabolic signals that promote aging

1 Excess adiposity is a major contributor to BP elevation, with estimates suggesting that obesity causes 65%-78% of primary hypertension cases

Wai KM, Mishra K, Koo E, et al

Inflammation and fibrosis can affect tubulo-interstitial lesions, and both glomerular and interstitial injuries will development of CKD

Common side effects include nausea, vomiting, and diarrhea during the first 24 weeks, typically resolved by week 68