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This narrative review synthesizes current preclinical and human evidence on the bidirectional interactions between GLP-1 RAs and the intestinal microbial ecosystem, with particular attention to microbial composition, metabolite production (including short-chain fatty acids and bile acids), intestinal barrier integrity, and inflammatory signaling

Neurophysiology (2017) 49(1):727

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In the same FDA drug safety communication, post-marketing cases of urosepsis and pyelonephritis were discussed, leading to the addition of warnings of severe infections to the prescribing information for these products

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For example, Rybelsus (semaglutide) is a daily oral GLP-1 receptor agonist authorised in the UK to treat adults with type 2 diabetes